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What mattered more on Sunday was the quality of the contest and, apart from a few aberrations, there could be no complaints about a final that was a fitting ornament to an excellent tournament.
Perhaps a few aberrations, a crowd-control tactic gone woefully wrong – one hoped so, but the numbers kept piling up, eye after mutilated eye popping up on the screens of phones and computers, as journalists began to publish their reports.
Interestingly, in almost every subtype there seemed to be 2 groups of tumors: one group with very few aberrations and one group with many aberrations (Figure 4).
Cluster A1 was characterized by few aberrations, which comprised recurring gains on 5p, 7p, 14q and 20q, and losses on 8p (Table S2).
Whereas solid tumors usually display complex karyotypes with many different types of chromosomal rearrangements, many hematological malignancies and certain sarcomas display only one or a few aberrations, usually balanced chromosomal translocations, which in some cases have been shown to be the initiating event in tumor development [1], [2].
This group generally displayed few aberrations per sample, mostly involving small gains and/or deletions.
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We could not assess whether patients who survived for longer periods showed less complex or fewer aberrations than the patients who survived less than one year.
Unexpectedly, however, patients with high JAK2V617F allele burden (>85%) displayed fewer aberrations.
The fewest aberrations were seen in ß-CTX (13 patients), estradiol (7 patients) and vitamin B12 (6 Patients) measurings.
Adenocarcinomas show fewer aberrations on average than SCCs, but share similar gains and losses (Wilting et al, 2006).
Many breast tumors in our cohort had numerous rearrangements on one or two chromosomes, while showing fewer aberrations elsewhere.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com