Excess PGE2 promotes excitatory signal transduction in the brain, leading to fever progression and behavioral abnormalities [ 8, 9].
Methylprednisolone was usually administered in the second week of the disease if any of the following occurred: a flare of fever, progression of clinical symptoms (such as dyspnea or diarrhea), a surge or resurge of CRP level, or rapid deterioration of chest radiographic findings (development of new infiltration).
Our study results suggest that the following may be clinical features of ARDS caused by HAdV-55: persistent high fever, rapid progression of dyspnea, need for mechanical ventilation support, elevated AST level and rapid progression from unilateral infiltrates to bilateral consolidations.
Despite efforts to elucidate the pathogenesis of dengue fever, the progression into severe disease remains poorly understood.
The PUO settled and she was discharged but returned 4 months later with recurrence of fever and further progression of splenomegaly.
These manifestations are often followed by an asymptomatic phase lasting from 2 to 10 days after remission from the fever, with possible progression to neurological disease.
Persistent high fever, dyspnea, rapid progression to respiratory failure within 2 weeks, together with bilateral consolidations and infiltrates during the same period, are the most frequent clinical manifestations of severe HAdV-55-induced ARDS.
Methylprednisolone, in the form of two to three pulsing doses of 500 mg to 1,000 mg a day intravenously, was administered to those with a persistent fever, radiologic evidence progression of lung infiltrates, or signs of respiratory distress despite the initial antiviral-hydrocortisone combination.
Call a doctor at the first sign of fever or rapid progression of symptoms such as vomiting or cough that includes difficulty breathing.
Persistent high fever, dyspnea and rapid progression to respiratory failure within 2 weeks, together with bilateral consolidations and infiltrates, are the most frequent clinical manifestations of HAdV-55-induced severe ARDS.
Secondary outcomes included comparisons of disease progression rates, fever clearance times, and measures of plasma viremia and quality of life between the treatment arms.
