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The fever effect on seizure threshold is well documented in human infants, however the associations between maternal perinatal stress and infants' susceptibility to seizures is unknown.
Inherent diversity of individuals in the responsiveness of their EC to TNF stimulation has recently been reported by Beck and colleagues in a study of cultured lines of HUVEC (Beck et al., 2006) and in the fever effect on PRBC cytoadherence in individual HUVEC isolated from Kenyan mothers (A.G. Craig, unpubl. data).
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The question I kept asking was: "why?" After the first incidents of fever-related improvements, I fell back on my training as a medical venture capitalist and consulted medical literature, where I found one Johns Hopkins paper from 2007 that documented the presence of a "fever effect" in some children with autism.
The agents of enteric fever induce their effect on the human body by invading the gastrointestinal tract and spreading in the bloodstream (Everest et al., 2001).
Fevers followed a predictable course, and it is not clear if treatment practices had any effect on fever resolution.
Fever has a detrimental effect on outcomes in patients with cerebral injury.
Known determinants such as maternal anaemia, child stunting, and child fever, have a positive effect on child anaemia.
Fever itself – without detrimental effect on outcome – does not require treatment with antipyretics or external cooling [ 64].
Furthermore, in a context of high parasitemia, it is possible that antibiotics might not have a measurable effect on fever clearance.
On the other hand, the full model show that higher prompt treatment using anti-malaria drugs for children with fever has significant reduction effect on childhood mortality when compared to lower prompt treatment.
Although it is widely accepted that fever has an adverse effect on patients with neurologic injury [ 38], little is known about the impact of temperature abnormalities on the outcome of other ICU patients, especially patients with sepsis [ 1, 18].
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