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Thrombin causes an outpouring of enzymes that can break down the fetal membrane, leading to preterm membrane rupture.
The injected adhesive would rapidly cure and attach to both the fetal membrane and uterine wall.
To develop the immunohistochemistry specific for meconium in the placenta, fetal membrane and umbilical cord.
Epidemiologic and experimental studies have demonstrated that thrombin causes fetal membrane weakening and subsequently PPROM.
Both agents (TNF-α and thrombin) cause fetal membrane weakening in the model system.
In a previous report, we demonstrated that 3 progestogens, progesterone, 17-alpha hydroxyprogesterone (17-OHP), and medroxyprogesterone acetate (MPA), each inhibit both TNF-α– and thrombin-induced fetal membrane weakening at 2 distinct points of the fetal membrane weakening pathway.
Cows were examined 1, 7 ± 3, and 14 ± 3 d postpartum for diagnosis of retained fetal membrane and metritis.
Further studies are needed to clarify our understanding of the role of fetal membrane aquaporins in amniotic fluid homeostasis.
GM-CSF is thus part of an overlap of the inflammation and abruption-induced fetal membrane weakening pathways.
"An approach that I still think is the most promising is to pre-seal the fetal membrane with an adhesive that would work where it is wet, before cutting through the membrane," he said.
The idea of pre-sealing is to use a needle to make a tented space between the uterine wall and fetal membrane without puncturing the membrane, and to then inject the sealant into the space.
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