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The lines with fertile rate more than 0% in the F1 population were excluded, and all the improved lines were showed complete sterility (0%) in the BC1F1 population.
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However, no significant improvements in G0 survival and fertile rates were observed when applying either version of the Cas9 nickase with paired sgRNAs compared with Cas9 nuclease and one sgRNA.
In the short term, an increase in the aggregate fertility rate is expected due to an increase in fertility amongst the least fertile women (a compositional effect).
Women aged 30-34 had the highest fertility rate of any age group since 2004, when women aged 25-29 were the most fertile.
The fertility rate of each line was scored as completely sterile (0%), partially sterile (1 30%), partially fertile (> 30 60%) and fertile (> 60%) (Govinda Raj and Virmani 1988).
If we use IVF as an example (albeit performed on subfertile rather than fertile couples) significantly higher fertilization rates were achieved with 20 000 sperm/egg versus 5000 sperm/egg (Tournaye et al., 2002).
Moreover, Professor George Fu Gao's previous international studies experience at Harvard and Oxford universities combined with his prolific rate of high quality scientific publication rate encouraged me to believe that the Chinese Academy of Sciences could provide a fertile environment for me to undertake scientific research.
The average differences in fertility rates between low and high fertile groups were 15.4% and 7.6% in Phase I and Phase II studies, respectively.
In contrast to findings with male raters, the relationship between women's attractiveness judgments and F0 variation was inconsistent; F0 variation predicted attractiveness for non-fertile females rating short-term attractiveness and fertile females rating long-term attractiveness.
Immunization of fertile baboons with synthetic form of LDH-C4 conjugated to DT resulted in 75% reduction in fertility rates [ 96]. (9) Sperm Agglutination Antigen-1 (SAGA-1).
We also focused on the survival and fertile G0 rates of sgRNA pairs that successfully generated heritable mutants with Cas9 nickase.
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