Both fer-1 and fer-15 do not suffer from matricide due to the lack of fertilization since their sperm production is affected [24], [25].
Ferrostatin-1 (Fer-1) inhibits ferroptosis, a form of regulated, oxidative, nonapoptotic cell death.
We found that Fer-1 inhibited cell death in cellular models of Huntington's disease (HD), periventricular leukomalacia (PVL), and kidney dysfunction; Fer-1 inhibited lipid peroxidation, but not mitochondrial reactive oxygen species formation or lysosomal membrane permeability.
This protein belongs to a family of mammalian proteins sharing homology with the Caenorhabditis elegans fer-1.
We developed a mechanistic model to explain the activity of Fer-1, which guided the development of ferrostatins with improved properties.
Yasunaga, S. et al. A mutation in OTOF, encoding otoferlin, a FER-1-like protein, causes DFNB9, a nonsyndromic form of deafness.
Two FER zeolites were used: NH4FER without any pretreatment (FER-1) and the same zeolite, dehydroxylated at 825 K (FER-2).
Among these analogs, the compound AA9 showed the best toxic activity on L. major (LD50 = 3.34 μM), which represents a 9 fold higher lethality as compared with its parental AA1 (Fer-1) compound (LD50 = 28.75 μM).
As shown on Figure 2A, fer-1 and fer-15 mutants are more resistant to C. neoformans, a pathogen that induces very high rates of matricide.
Strains used for H3K9me2 ChIP-seq analysis were fer-1 (b232ts ); him-8 (e1489 ) and fer-1 (b232ts ).
Overall, ∼99.9% of the enriched sites present in fer-1 were also enriched in fer-1 ; him-8.
