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PHREEQC was used for applying evaporation with continuous water feeding model to simulate perspectives of solar-powered desalination unit (Fig. 1).
We investigated the role of OPN in the early development of insulin resistance using a 2-4 week HFD feeding model [12].
In our study we have used the every-other day feeding model (EOD), which is considered to produce only a mean of 15% deficit in the calorie input due to the fact that animals eat more when they have access to food [24].
A palatable scheduled feeding model, described by Berner et al.
In an Anopheles stephensi mosquito feeding model, harmonine displays transmission-blocking activity.
To understand the mechanisms by which chronic alcohol consumption and endotoxemia initiate pancreatic injury and AP, the well-established Lieber DeCarli alcohol feeding model was used.
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We selected this voluntary feeding model, instead of genetic models of obesity or forced feeding models because our model reflects best the human situation wherein primarily eating habits, besides genetic constellations cause NAFLD and obesity.
For example, possible effects of probiotic bacteria or particular diets on the gut barrier can be studied using organ culture models [ 230] or feeding models [ 13, 231].
Please see above (response to Reviewing Editor) where we expand on how we address this caveat in this revision, and where we also explain the conceptual difficulties inherent in expanding Exps. 3 and 6 to include conditioned feeding models.
MiR-31 up-regulation was also described in human HCC samples and in a similar C57BL/6J high-fat diet fed model [ 17, 51].
We recommend further studies to use the Watanabe hereditary hyperlipidemic (WHHL) rabbit model where atherosclerosis already happened and no time is needed for induction of atherosclerosis as compared with cholesterol fed model of atherosclerosis.
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