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The binding to the receptor on its own cell plasma membrane initiates a positive feedback loop of growth stimulation as well as it initiates a cascade of events leading to the expression of genes involved in cell cycle progression, cell growth and apoptosis resistance [17], [18], [19].
A positive feedback loop of growth factor signaling has been described in Src transformed human pancreatic cancer cells.
Stellate quiescent cells are triggered to proliferate by high molecular weight serum factors [ 15] and may be subjected to a positive autocrine and paracrine feedback loop of growth factor stimulation.
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It added that there was a risk investors would demand high interest rates and that tougher financial conditions would create a "pernicious feedback loop" of fragile confidence, lower growth and inflation, and rising debt.
Indeed, when HDFs/MEFs are propagated in hypoxic conditions (1-31-3%ather than the commonly used 20% oxygen, HDFs/MEFs avoid senescence; when grown in 20% oxygen, HDFs/MEFs rapidly accumulate DNA damage and eventually initiate a positive feedback loop of oxidative damage and growth arrest that masquerades as cellular senescence [ 51, 52].
Additionally, AKT phosphorylation has been described through a feedback loop of the PI3K/AKT/mTOR pathway from the insulin-like growth factor I receptor (IGF-IR) (O'Reilly et al, 2006).
The growth of health insurance can trigger a self-perpetuating feedback loop of political power by those who provide clinical care.
This creates a feedback loop of weak hiring: Every company that declines to hire and expand -- minimizing opportunities for growth throughout the economy -- simply reinforces the concerns of other companies, further discouraging anyone from hiring.
It's probably a feedback loop of both, Gambetta says.
There is a feedback loop of recrimination playing in the streets of Ferguson.
Jenna Wortham: That feedback loop of positive reinforcement is the most addictive element of social media.
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