An important aim of bone regenerative medicine is to design biomaterials with controlled chemical and topographical features to guide stem cell fate towards osteoblasts without addition of specific osteogenic factors.
Breast cancer cells may develop biological features analogous to stem cells, especially when they undergo epithelial-mesenchymal transition (EMT) [18] or acquire amplification of human epidermal growth factor receptor 2 (HER2) gene [19].
Strong evidence is emerging supporting the hypothesis that cancer stem cells with similar features to normal tissue stem cells are resistant to standard chemotherapy and drive tumour regrowth after therapy finishes [ 9].
The analysis of CFEs in the initial, primary, culture and in the first passage indicate that α6+/MHCI- cells have higher proliferative potential than α6+/MHCI+ cells, another feature attributed to stem cells.
Previously, we selected different features to predict single- and multi-stem pre-miRNAs, respectively [ 24].
We designed 94 features to describe each duplex window, including position-specific structure features, distances to the stem loop, and minimum free energy characterizing the stability of the RNA molecule.
The purpose of this study was to evaluate the effect of cabozantinib to stem-like features and therapy resistance.
The availability of genetic tools to label and lineage trace single cells has allowed us to understand several features of stem cells in their natural intact environment (Doupé et al., 2012; Mascré et al., 2012; Simons and Clevers, 2011; Snippert et al., 2010; Van Keymeulen et al., 2011).
In order to unveil some of the crucial stem cell-niche interactions and expedite the implementation of stem cells in clinical and pharmaceutical applications, in vitro methodologies are being developed to reconstruct key features of stem cell niches.
In a previous study, we examined the gene expression profile of CIS cells and found many features common to embryonic stem cells indicating that initiation of neoplastic transformation into CIS occurs early during foetal life.
In this situation, cells grow in perfect spheroids, termed mammospheres, and show the two classic features of stem cells: the ability both to self renew and to differentiate.
