While PCA offers dimension reduction in constructing summary exposure features, shrinkage-based regression, e.g., least absolute shrinkage and selection operator (LASSO) or ridge regression, may be helpful in dealing with large dimensional models through variable selection [ 42].
However, the fidelity of the features can be compromised by incomplete feature cavity filling and feature shrinkage during the forming process.
Semi-thin sections of LR-White embedded cells stained by toluidine blue showed a large number of OUMS-27 cells treated with 15d-PGJ2 with characteristic apoptotic features; cell shrinkage and nuclear condensation.
The features of nonuniform shrinkage are rather peculiar: (1) Up to 40%60%% conversion, the particle shrank uniformly.
Fluorescent assays revealed characteristic apoptotic features, including cell shrinkage, nuclear condensation, and marked decrease in mitochondrial membrane potential in SF-3 treated cells.
The focus of this experimental work was on the injection stage, investigating the effects of processing parameters and blade geometrical features on the shrinkage of critical dimensions.
In addition, the cellular microstructure in drug treatments showed no significant change; while SVCV-infected cells were seriously shrunk, and observed typical apoptotic features including cell shrinkage, volume reduction and cell blebbing.
As shown in Figure 3B, ZnO NP-exposed cells displayed typical apoptotic features, including nuclear shrinkage, chromatin condensation, and extensive cytoplasmic vacuolization after 6 h of exposure to 12 μg/ml of ZnO NPs as compared to the unexposed control cells.
Color and consistence are evident at a glance, while other features such as shrinkage and surface modifications are more subtle.
Apoptosis, so called programmed cell death (PCD), is characterized by specific morphological features of cell shrinkage, nuclear condensation and fragmentation and membrane blebbing in the cells [ 3].
Phase-contrast photomicrographs revealed that U0126-treated HepG2 cells displayed typical features of apoptosis: shrinkage of cytoplasm and membrane blebbing (Fig. 6).
