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In short, the pharmacokinetic features of TCS are very similar to BPA in both humans and mice.
In this study, we have introduced a new approach to identify new members of known classes of ncRNAs based on the features of TCs corresponding to known ncRNAs.
However exploring the relationship between domain and gene organisation has the potential to unveil mechanistic features of TCS signalling/evolution, as it has done for minimal TCS [ 16].
Mice haplo-insufficient for Tcof1 replicate some of the core features of TCS and demonstrate a crucial role for Tcof1 in the craniofacial neural crest (Dixon et al., 2006).
In this study we have used a rationally-devised scheme to classify gene and domain architectures of prokaryotic TCS genes and in doing so, identified general features of TCS organisation.
Our analyses provide a baseline for comparison with individual organisms, and to such an end, we have also proposed two new metrics of TCS organisation that should prove useful in teasing apart features of TCS organisation and evolution.
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The structural and functional features of TC-element-containing genes were distinct from those of TATA-box- or TATA-variant-containing genes.
In vitro studies have shown that, as a key feature of TCs, the increment of androgen production was driven by LH in a dose-dependent manner [ 5, 11, 12].
Their data demonstrated that the differential expression of subset of genes in chromosomes 17 and 18 were unique features of pulmonary TCs, and they might be used as biomarkers to distinguish TCs from the other type of cells.
On the other hand, the sample prepared at 860 °C under 350 MPa for 48 h exhibits the worst characteristic features of high Tc-phase as a consequence of the enhancement in local structural distortions, dislocations, defects and disorders in the Cu O2 consecutively stacked layers.
This provides the mechanism that establishes critical features of the TC input to the barrel cortex and may also account for similar features of this input observed in other primary sensory areas of neocortex.
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Justyna Jupowicz-Kozak
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