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In addition, the transected contour of each neuronal cytoplasm including visible dendrites on KB images was traced manually on the same software (Pannoramic viewer) to automatically calculate the perimeter (μm) and area (μm) of each neuronal cell body in which Nissl granules or lipofuscin, as features of neurons, could be visible in KB.
The transplanted cells are "expressing certain features of neurons, but there's a lot we don't know," says Ron McKay, a developmental neuroscientist at NINDS.
Dendritic spines, the bulbous protrusions that form the postsynaptic half of excitatory synapses, are one of the most prominent features of neurons and have been imaged and studied for over a century.
The strict definition of 'organelle' allows for the inclusion of phenotype-defining features of neurons such as axons, dendrites and in the case of the special senses, modified primary cilia.
In addition, the simplified model neurons used here provide for easier analysis and comparison with mean-field models such as the Wilson-Cowan equations; by contrast, Brunel et al. use integrate and fire neurons which account for more biophysical features of neurons.
Studies in brain slices have provided a wealth of data on the basic features of neurons and synapses.
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But did he miss an important feature of neurons?
Another characteristic feature of neurons is the existence of processes that evolve on multiple time-scales.
DOI: http://dx.doi.org/10.7554/eLife.06953.002 The discovery of bona fide synapses formed on non-neuronal NG2-expressing cells (Bergles et al., 2000), the progenitors of myelinating oligodendrocytes, has challenged the dogma that synapses are a unique feature of neurons in the central nervous system.
In addition to the unique feature of neurons of communicating messages over long distances by electrical signals, it has been recently proposed that the long-range physical translocation of proteins from remote dendritic sites towards the soma can convey information to the nucleus.
The two shared features (rows of neurons) were activated for each training example, along with ten other features chosen randomly from that particular category's pool of (15) non-shared features.
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