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It is noteworthy that PC3 cells (a prostate cancer cell line) forcibly over-expressing osteopontin develop many features of migratory metastatic cells [ 7] but do not act as instigators in this model.
We have previously shown that Vegfa 120/120 mice have significantly fewer migrating GnRH neurons and demonstrated that VEGF164 signals through NRP1 to promote the survival of GN11 cells, which recapitulate many features of migratory GnRH neurons (Cariboni et al., 2011).
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Induction of JAK/STAT signaling, as reflected by the expression of many interferon-inducible proteins, may represent a general feature of migratory cells, and was observed in both branching and malignant invasive cells.
The unique capacity of the PKT assay we developed to highlight and quantify individual features of the migratory phenotype, could then link a given pro-migratory gene to specific migratory mechanisms.
PKT segmentation and morphometry provided important insights into the basic features of the migratory process.
The high-throughput migration assay described herein, and the imaging software developed for measuring different features of the migratory process, provide a rapid, reliable and quantitative approach for assessing cell migration in diverse cell types, cultured under varying conditions, and exposed to a variety of chemical or genetic perturbations.
In the same pathway MET, TGF-βR, and two members of the Rho-family GTPase, Rac, and cdc42 all implicated in the loss of adherence features and acquisition of migratory and cancer properties were regulated, as well.
Christian Kälin of Henley & Partners, a Swiss-based law firm specialising in what it terms "citizenship planning", says a more formal tolerance of dual nationality there is likely.For many ordinary citizens, dual passports still seem dodgy: a convenience for the cosmopolitan few or a sop to the menacing many, rather than a natural feature of a migratory world.
This suggests that the dynamic behavior documented here is highly conserved and suggests further that it may be a feature of all migratory eukaryotic cells.
This is not particularly remarkable since the return migration is a typical feature of all types of migratory streams.
One of the main migratory features of dermal fibroblasts is the extension of their filopodia along the collagen matrix [33], [34], [35].
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