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It is well known that one of the main clinical features of malaria at an individual level is a fall in hemoglobin (Hb), often resulting in anemia [11], [12], [13].
However, P. ovale may interact with other species of Plasmodium infecting humans, such as P. falciparum and P. vivax, and may have a major influence on the epidemiological features of malaria [5].
To evidence pathological features of malaria during the course of pregnancy and in the developing fetus, this infection period was determined to be the optimal time point as earlier infections did not allow reaching pregnancy at term (data not shown), which is consistent with previous reports [26], [27], [31].
Secondly, whilst one may argue that some aspects of malaria epidemiology are not well-captured within our proposed compartmental framework, we believe that it captures the main features of malaria epidemiology that will impact at a qualitative level on the dynamics of disease incidence following an intervention.
The main epidemiological facies (features) of malaria in Africa are found in Madagascar.
patients presenting with clinical features of malaria sent for microscopy investigations after giving informed consent.
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Retrospective analysis of paediatric ward admission books from Dedza and Mangochi district hospitals for January December 2004 (Mangochi n = 1579; Dedza n = 1165) showed that there were also significant differences in the features of malaria-related admissions between the two districts.
Anemia, body weight loss and body temperature reduction are the general features of malaria-infected mice [ 41].
We assessed fever as the principal clinical feature of malaria, by measuring temperature at the time of blood sample collection and we also estimated the occurrence of fever during the previous 2 weeks using a questionnaire.
In addition, cachexia is an important feature of malaria pathology [ 27].
Hence, platelet count is being evaluated as a predictor and prognostic feature of malaria infection [ 11].
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