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In this work, an extended numerical study on the effects of materials properties and geometry features of inclusions is conducted in order to better understand the deformation mechanism and mechanical properties of this kind of composites.
Next, we investigated whether enhanced propagation of C. trachomatis in Irga6−/− MEFs was connected with a lack of autolysosomal features of inclusions.
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Article number 333 on his long CV is "Demographic and Clinical Features of Inclusion Body Myositis," a paper co-authored with David Paltiel '85, a professor of public health and management at Yale.
Ubiquitinated inclusions found in muscle, bone and brain are a feature of inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD), which can lead to disabling muscle weakness (Inclusion body myopathy-IBM), osteolytic bone lesions (Paget's disease of bone-PDB), and neurodegeneration (FTD).
In addition, identifying the key features of viral inclusions could provide means to control their formation and maintenance during IAV infection.
TIF from spinal cords of mutant mice are also enriched in polyubiquitinated proteins (Figure S1), and therefore have the fundamental biochemical features of protein inclusions in SOD1-linked ALS.
Furthermore, Ast-HI in spinal cord of L84V SOD1 transgenic mice at symptomatic stage also showed KDEL positive (Fig. 6G and H), meaning that the principle features of these inclusions in neuroblastoma cells and the LBHI/Ast-HI of FALS patients are the same and implying LHI and LBHI/Ast-HI might develop in similar procedure.
These properties are compatible with features of VAPB inclusions.
Poly-GA expression in HEK293 cells recapitulates all known features of DPR inclusions seen in C9orf72 patients, without causing toxicity (Fig. S2c).
By measuring IR signatures of different protein deposits that had been spatially localized by immuno-fluorescence microscopy, the authors established that the structural features of intracellular Huntingtin inclusions are nonuniform and display localized degrees of polymorphisms and β-sheet contents.
Neurodegenerative diseases are characterized by a number of features including the formation of inclusions, early synaptic degeneration and the selective loss of neurons.
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