Developing individualized, "targeted" therapy for each AML patient based on unique molecular features of disease remains a daunting goal, yet one that we can now begin to envision.
Overall, the future of HCC treatment will rely on an understanding of the interplay between etiological factors, molecular features of disease, and rational therapeutic intervention.
In the context of human disease, interruptions may present with different manifestations, or different clinical features of disease being dominant.
Two other relevant examples are macrophage activation syndrome and rheumatoid arthritis - diseases where uncontrolled macrophage proliferation or macrophage resistance to apoptosis, respectively, represents important features of disease pathogenesis [77], [78].
It will be important to dissect the putative mechanisms by which angiopoietins may contribute to malaria pathogenesis in animal models where endothelial and BBB dysfunction and vascular leak are central features of disease [25].
Hip dysplasia is probably unique among companion animals in the provision of such a large quantity of data on so many of the features of disease, but the disease and the screening data is complex, reflecting underlying genetics, environmental effects and the debilitating developmental consequences of innate malformation.
Some of the main features of disease are synovial hyperplasia and mononuclear cell infiltration.
Models with few strains are easier to analyze, but may miss important features of disease dynamics.
This was accompanied by a significant reduction in the histological features of disease.
They probably contribute to certain features of disease, namely tissue destruction and synovial hyperplasia.
Human NIDDM features resemble with the clinical and pathological features of disease in OLETF rats.
