Further, we elucidated a mechanism by which TAS2R agonists mitigate features of asthma.
Key features of asthma namely airway inflammation, remodeling and hyperresponsiveness were assessed respectively.
Here we aimed to determine the effect of TAS2R agonists on features of asthma.
We have previously shown that TAS2R agonists are potent bronchodilators, yet their effect on key features of asthma remains undetermined.
IL-13 is central to Type 2 inflammation and contributes to many features of asthma.
van Rijt, L.S. et al. In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma.
Here we used two different mouse models of allergic asthma to assess the effect of TAS2R agonists on key features of asthma.
Using broad-tuned ligands allowed us to discern the effect of bitter tastants on multiple features of asthma pathogenesis in mice.
In this review, we describe preclinical in vivo models that recapitulate many of the features of asthma and COPD.
We examined the role of IL-18 in preventing the development of and in reversing established allergen-induced airway inflammation and airway hyperreactivity (AHR), the cardinal features of asthma.
Epithelial features of asthma and COPD can be modelled by using a variety of disease-related invoking substances either alone or in combination, and by the use of primary cells isolated from patients.
