Sentence examples for feature of transformation from inspiring English sources
A key feature of transformation is the loss of cell contact inhibition and organisation.
The cytoplasmic accumulation of hnRNP K seems to be an intrinsic feature of transformation per se, and does not merely reflect the increase in cell proliferation.
Disorganisation of the actin cytoskeleton is a characteristic feature of transformation (reviewed in Pawlak and Helfman, 2001) and the potential to reinstate normal cytoskeletal structure and function represents a promising target for cancer therapy.
When TRK oncoproteins activity was blocked by K252a inhibitor, NIH3T3 foci underwent morphological reversion and STAT3 protein raised to a level comparable to NIH3T3 cells, indicating that Stat3 reduction in transformed foci correlated to morphological features of transformation driven by TRK kinase activity.
Genomic features of transformation such as loss of heterozygocity or chromosomal rearrangements cannot easily be reversed.
Given evidence that ectopic expression of DKK1 suppresses features of transformation in tumor cells [18], [19], [20], DKK1 might inhibit tumorigenicity.
No definitive features of transformation to a more aggressive histology were evident.
Rheumatoid synovial tissues and synovial fibroblasts exhibit some features of transformation, including autonomous invasion into cartilage, expression of oncogenes, loss of contact inhibition, and insufficient apoptosis [ 41- 44].
They are also being examined for the presence of EBV-DNA and EBNA, and other features of transformation, including malignant tendency, by passage through athymic nude mice.
Importantly, we recently showed that when TBX2 is silenced, we are able to reverse several features of transformation in both breast cancer and melanoma cells.
These cells exhibit some features of transformation in RA, including loss of contact inhibition, anchorage-independent growth, oncogene activation, autonomous invasion into cartilage and somatic gene mutations [ 4, 6- 9].
