The categories are "current situation", "usage", "game features" and "efficacy to lesson" respectively.
Gene therapy represents a promising cancer treatment featuring high efficacy and limited side effects, but it is stymied by a lack of safe and efficient gene-delivery vectors.
Next, we tested if the potent in vitro activity of C1A combined with its favourable PK features favoured efficacy in the human cancer xenograft models.
Next, we tested whether the potent in vitro activity of ICEC-0782 combined with its favourable pharmacokinetic features, favoured efficacy in the human cancer xenograft models.
Clinical features and efficacy of treatment in Japanese FMF patients vary widely according to the specific MEFV gene mutation, and therefore genetic analysis should be performed for diagnosis in cases of Japanese FMF.
As clinical features and efficacy of treatment vary widely according to the mutation(s) present, comprehensive diagnosis including clinical data and genetic analysis is needed for Japanese FMF patients.
The focus of our future preclinical proof of concept studies in animal models of B-lineage ALL studies will be a stepwise evaluation of the safety, biocompatibility, pharmacodynamics features, and efficacy of this polypeptide-based nanoscale formulation of CD22-RTM.
Although transgenic mutant SOD1 animals, which provide the most widely studied models of the disease, display many of these features, therapeutic efficacy in these animals has been poorly predictive of human efficacy, and it is not clear the degree to which studies in these models overexpressing a gene implicated in a small subset of human cases will prove applicable to human disease.
Because sites under selective pressure preferentially possess molecular features required for efficacy, inclusion of the site-conservation feature indirectly recovers some of the information that would otherwise be lost when informative molecular features are missing or imperfectly scored.
Chirality is often an important feature of drug efficacy; the dihydropyridine-sensitive (L-type) voltage-gated calcium channel blocker Bay-K 8644 -S enantiomer activates, while the -R enantiomer blocks these channels [37].
