However, the major constraint for explorative or combinatorial metabolic engineering approaches is the availability of a feasible screening method to select the desired phenotype from a large population in a high-throughput manner.
To identify the targeted patient population, feasible screening strategies exist (Kenny et al. 2011; Reuben et al. 2003), and can be implemented particularly effectively in settings with an electronic health record (Spears et al. 2013; Wenger et al. 2010) or care management system (Wenger et al. 2011).
A fasting insulin value >20 μU/mL, HOMA value > 3.8, and glucose/insulin value <7.2 were reasonable screening values in our population of white women, whereas a fasting insulin value >23 μU/mL, HOMA value >4.5, and glucose/insulin ratio <4.0 were feasible screening values in Mexican American women.
If further validated and improved in future studies, these results may be applied to a feasible screening regimen, either in high-risk population or even in the general population, to detect this cancer at potentially curative stages.
In resource-restricted rural/semi-rural environments, identification of feasible screening tools is a priority.
The translated MDQ was found internally consistent (alpha 0.79) and a feasible screening tool.
However, because of its invasive nature, RHC is not a feasible screening tool for the SSc population.
Feasible screening instruments are needed to improve recognition and diagnosis of the various forms of the illness.
Concurring with other studies [ 33, 34], our results encourage consideration of TBLU as a viable and feasible screening method in high-prevalence and low-resource scenarios like India.
The checklist is a feasible screening method for potentially remediable problems which are cumulatively a significant contributor to cancer patients' distress.
