Given the limited time of 4 weeks for country visits, the need to spend several days in each country and the need to visit as many countries as feasible the rationale for selecting Kyrgyzstan, Kazakhstan and Tajikistan in Central Asia and Georgia and Armenia in South Caucasus included; 1.
Clinical TCR gene therapy of melanoma represents a feasible and promising treatment rationale yet is currently challenged by objective response rates that stay behind those observed with conventional adoptive T cell therapy.
Applications of new technologies and appliances are technically feasible and have an economic rationale.
Nevertheless, although we totally agree with Bruel and colleagues that the intervention is safe and feasible, and that a clear biological rationale for the earliest possible induction of therapeutic hypothermia exists [ 2- 5], we doubt that a prospective randomised trial on additional prehospital cooling is feasible and justifiable.
Establishing a feasible and safe PK-guided dosing strategy could provide a rationale for a large prospective clinical trial.
Considering the aim of presenting a well-elaborated training concept with a strong theoretical rationale, in this paper we demonstrate that Gentile's taxonomy presents a feasible template providing assistance for developing and implementing a theory-driven rehabilitation program.
If it is not deemed necessary or feasible, existing recycled water quality may be adequate to achieve project goals depending on project rationale, site and water quality evaluation, and public acceptance.
We have demonstrated that it is feasible to develop interventions to change professional practice that are underpinned by a robust, scientific rationale.
Based on the above rationale, we have prospectively evaluated a combined regimen consisting of hyperfractionated radiotherapy, doxorubicin, and, when feasible, debulking surgery in 55 consecutive patients presenting with ATC.
We developed an intervention according to guidelines for complex interventions (see rationale for the intervention in the methods section) 22 23 and that we have shown was feasible to deliver and promising in our pilot randomised controlled trial.
This paper describes the rationale and protocol for a pilot randomised controlled trial (RCT) of IBPI designed to assess how feasible it is to implement an online parenting intervention for parents with BD.
