The initial population of solutions is generated through a random exploration of the search space, which is defined using feasible intervals of values for the parameters.
The initial population of solutions is generated through a random exploration of the search space, which is defined using feasible intervals of values for the variables (Sup. Mat. A2 [see Additional file 1]).
This is achieved by defining a feasible interval for each control parameter shown in Table 9, which assures the stability of the system.
Each parameter has a feasible interval that guarantees the stability of the system within the defined gain limits.
This could imply that the system is designed to have the maximum sensitivity to the intensity of the stimuli within the biologically feasible interval.
The remaining calculable fluxes lie within their feasible intervals (and none of them is at its min/max boundary).
In this context, a statistical ensemble is a large number of system replicates, each with randomly sampled model parameters from biologically feasible intervals.
Otherwise (k3 ≤ k1), single activation rate (rSA) dominates over the whole interval of feasible concentrations for the protein (0.0 1.0).
When the value of k3 increases the position of Peq is shifted to smaller values of P. In order to establish the domain of values for the rate constants in which the mechanism is effectively dual, we fix an interval of feasible values for the parameter k3 with respect to k1.
Subsequently, unlike the BFS-level algorithm, the ordering in the vertex sort algorithm permits nodes to span an entire interval of possible positions with any feasible ordering.
