Intra- and close postoperative catumaxomab seems feasible, but efficacy and safety were limited by postsurgical complications.
A preliminarily feasible and efficacy-suggesting SMAART trial could inform the future design of a multi-center, double-blinded, placebo-controlled, randomized trial comparing the clinical efficacy of the polypill strategy for vascular risk moderation among stroke survivors in LMICs.
The addition of Erlotinib to chemoradiation in inoperable NSCLCs is feasible with interesting efficacy profile.
With the proof-of-concept evidence from the current study completed, it then becomes feasible to conduct efficacy studies with a larger sample under more varied implementation conditions.
24 These data suggest that ameliorating the toxicity profile of the docetaxel + cisplatin + 5-FU regimen is feasible without jeopardizing efficacy.
Therefore, it is feasible that the efficacy and safety profile could be different when aspirin is used specifically as a treatment for ARDS in ICU.
In summary, the approach of using sequential carboplatin followed by paclitaxel/gemcitabine is feasible, and the efficacy data are encouraging; however, the incidence of pulmonary toxicity is of some concern and may limit the use of this weekly regimen.
This phase II study shows that a novel 2-weekly schedule of capecitabine plus irinotecan as first-line treatment for MCRC is feasible, with notable efficacy and safety, even in older patients.
The administration of bevacizumab in addition to a standard neoadjuvant capecitabine-based chemoradiotherapy regimen in patients with LARC is feasible and its efficacy is sufficient to justify further randomized studies.
Coordinated neonate vaccination generating additional concerted widespread reductions (herd effects) in infectious reservoirs is feasible, even with low efficacy vaccines [354].
