a significant and unique sub-map alignment; an alignment labeled as non-significant and/or non-unique (which will be considered as a false alignment); or no feasible alignments found.
To evaluate the statistical significance of a candidate alignment, we exploit the fact that we have explored the space of feasible alignments in our search and use these alignments to approximate a random sample from a (conservative) null model.
Each glocal alignment sub-problem will then return either: (i) a significant and unique sub-map alignment; (ii) an alignment labeled as non-significant and/or non-unique (which will be considered as a false alignment); or (iii) no feasible alignments found.
Alignment of larger genomes is feasible; pairwise alignment of Drosophila melanogaster and Drosophila yakuba requires less than 3 hours on a single computer, while alignment of the human and mouse genomes requires 90GB RAM and about 32 compute hours.
Further improvements are feasible: straight alignment of the optical fibre bundle without a mirror could reduce light losses, and an integration time increase could compensate for them.
Although this approach guarantees maximal sensitivity in the case of unfiltered data, it is in general not feasible, and alignments have to be filtered stringently.
In order to make this method feasible, a reliable alignment technique for PET scans is paramount.
Alignment feasible up to various length scales (from mm to m).
The fundamental assumptions which render interference alignment feasible are that there are multiple available dimensions (space, frequency, time or code) and that the transmitter is aware of the CSI towards the non-intended receiver.
