Our study demonstrates the feasibility and potential power of discovering cell type-specific miRNA biomarkers in complex tissue using combination of LCM with genome-wide miRNA analysis.
By comparing the miRNA expression profiles of colorectal tissues in the mixed cell types with the pure epithelial cells, we demonstrate the feasibility and potential power of discovering miRNA biomarkers in complex tissue using the combination of LCM with genome-wide miRNA analysis.
Our results demonstrate the feasibility of utilizing biomarkers discovered by global expression profiling analyses for the detection and diagnosis of OTSCC.
We demonstrated the feasibility of this platform by discovering more than 13,000 polymorphic markers in two different organisms and by rapidly mapping three traits in two bulk segregant populations and 96 individuals, using less than half the capacity of one run on an Illumina Genome Analyzer.
We investigated the feasibility of using Ontology Fingerprints to discover associations between genes and PubMed articles, as well as to disambiguate gene name mentions.
This study was conducted to explore the feasibility of using the Affymetrix GeneChip to discover and map SFPs in the large hexaploid wheat genome.
This study also demonstrated the feasibility of using microarray transcriptional profiling to discover phytoestrogenic components that are present in natural products.
Objective: To examine the relationship of premorbid variables, injury severity, and cognitive and functional status to outcome 1 year after traumatic brain injury (TBI) and to assess the feasibility of multivariate path analysis as a way to discover those relationships.
The goal of this study was to explore the feasibility of incorporating the available online bioinformatics databases to discover Arabidopsis genes specifically expressed in certain organs, in our case immature seeds.
The main objective of this study was to investigate the feasibility of SCO2 injection for enhanced gas recovery for a newly discovered gas field situated in the North West Shelf of Western Australia.
