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Take a look, for instance, at the once-popular Zicam zinc nasal spray, which the FDA removed from the market in 2009.
In 2011, the FDA removed the warning label for liver injury and requirement for monthly liver function testing for ambrisentan on the basis of postmarketing data involving more than 7,800 patient years.
Similarly, in 2007, the FDA removed the claim for ESA-related QoL improvements in patients with chronic kidney disease from the product labels because of a lack of evidence from well-conducted trials.
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In 1983, Bendectin®, the only FDA-approved drug for NVP, was removed from the market by its manufacturer due to legal costs based on claims of teratogenicity, which were subsequently proven to be unsubstantiated.
(See "FDA: Ranbaxy Botched Manufacturing") Although the FDA did not actually remove any products from the shelves, or advise consumers to stop buying Ranbaxy generics, evidently the blocked-off import channel has led to losses on inventories.
Solvay Pharmaceuticals removed DBP from its new FDA-approved formulations of pancrelipase capsules in April 2009.
Some controversial uses of pharmacy compounding include the introduction of drug moieties that have been denied or removed from the US market, the mass marketing of specific, non-FDA-approved formulations, and the compounding of drugs for economic reasons.
The list of drugs was refined to focus on only FDA-approved drugs by removing experimental and withdrawn drugs, which resulted in 313 L. major genes being linked to 257 FDA-approved drugs.
When America's Food and Drug Administration FDAA) removed Vioxx, a troublesome painkiller made by Merck, from the market in 2004, it cost the firm billions of dollars in lost sales and in legal payouts to the families of victims.This week, investors feared the same fate awaited GlaxoSmithKline (GSK), a giant British rival.
ESA manufacturers were required to remove from FDA-approved product labels all statements related to potential QOL benefits with ESAs in the cancer setting.
Nestle USA announced this week that it will remove artificial flavors and FDA-certified colors from all of its chocolate candy.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com