Finally, the HFD and HFD plus ActRIIB-Fc groups had comparable 24-h food intake, supporting the idea that ActRIIB-Fc effect on body composition is not simply the result of an ActRIIB-Fc-mediated hypophagia (Fig. 1G).
For example, our studies determined that the ActRIIB-Fc effect on HFD feeding is not due to hypophagia, but based on the data from our studies, we cannot rule out the possibility that there is a difference in nutrient absorption between the groups that could be contributing to the reduced adiposity in the ActRIIB-Fc treatment group.
Therefore, targeting GDF-3 and/or other ligands with a similar function is sufficient to offset the effects of HF feeding, so it is likely that the ActRIIB-Fc effect on WAT is contributing to the net effect of prevention of DIO.
Finally, we identified multiple ligands capable of reducing thermogenesis that represent likely target ligands for the ActRIIB-Fc effects on the white fat depots.
We identified GDF-8, GDF-11, activin A, activin B, and GDF-3 as potential mediators of the described ActRIIB-Fc effects in WAT.
To minimize potential influences of motion-induced spurious effects into FC the effects of motion (as assessed through means of the 6 motion parameters resulting from image realignment) were also regressed out of the resting-state time-series.
However, the observed decreasing behavior of both the FC memory effect and the SEB field with the increase in the NiO nanoparticle size strongly indicates that the memory effect in NiO nanoparticles is mediated by strongly pinned interfacial spins.
A club statement said: "John Sheridan has resigned from his position as manager of Chesterfield FC with effect from 18 September.
Such structural change resulted in an obvious increment in ECL intensity due to the decreased Fc quenching effect to the ECL substrate.
The observed FC memory effect decreases with increasing particle sizes and disappears when the nanoparticles exceed ~30 nm NiO (see Additional file 1: Figures S2(a)–(c)). Figure 5b shows the absence of the memory effect in the 54-nm NiO nanoparticles.
