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To preserve psychological integrity, a more holistic portfolio of favoured outcomes is needed.
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In general, HCPs were supportive of using outcome measures as an adjunct to support clinical opinion, but some raised concerns about favouring outcome measures over clinical judgment [ 4, 15].
The major limitation of this review is likely publication bias favouring better outcomes, as poor outcomes are less likely to be reported.
Only in patients aged under 30 did the trend not favour outcomes after use of alteplase.
With 70 percent pre-existing immunity and lower bound vaccination coverage, reducing vaccine effectiveness to 60 percent or lower resulted in the attack rate-based strategy becoming favoured over outcome-based, when evaluating total deaths as the outcome of interest.
In studies that considered more than one outcome using MTCs, we favoured the efficacy outcome over safety outcomes.
3 16 In this study we did not examined whether outcome-reporting bias favoured significant primary outcomes, but we did find that studies in favour of the experimental intervention were published more frequently than studies in favour of the control intervention.
Despite these differences, which clearly should favour better outcomes in the SITS group, there was no difference in unadjusted good or poor outcomes between the two groups.
A suspicion thus gains ground that the way in which the IPCC sythesises, generalises and checks its findings may systematically favour adverse outcomes in a way that goes beyond just serving the needs of policymakers.
In two patients, contrast CT was unable to be used due to renal impairment, potentially favouring the outcomes of PSMA PET in these cases.
The emerging picture would seem to favour improved outcomes and yet the pattern of major neonatal morbidities (fig 2) is strikingly similar to that in 1995.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com