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On one hand, ethnically homogenous populations like our Caucasian population are favourable to detect possible pathogenetic determinants, but one must bear in mind that the size of our RDS population is limited and the total numbers of neonates studied for each polymorphism vary slightly according to the recruiting time point.
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It is probable that the reaction conditions in the 2% homogenate was most favourable to detecting these molecular interactions.
For example, designing a trial with favourable power to detect the smallest difference that would be clinically worthwhile using evidence from related studies (e.g. drugs in the same class etc)., ideally taking the uncertainty in the estimation into account [ 28].
Both Classic and recent Maya held the tzolkin as the most sacred means of divination, enabling the priests to detect the favourable or evil influences attached to every day according to the esoteric significance of the numbers and the day-signs.
The mutation rate may therefore have been less of a constraint on domestication than the ability of early farmers to detect and fix favourable phenotypes.
If domestication depended on de novo occurrence and selection of mutants in crop populations grown by early farmers, then improvement would probably have proceeded slowly, limited by the mutation rate and the ability of early farmers to detect and propagate favourable phenotypes.
These more favourable conditions might have allowed them to detect the very early response at sensor level at a higher rate than us.
As there were only 21 patients (6.2 %) in our cohort who regained a favourable neurological outcome, the statistical power may be insufficient to detect the difference between patients with and without a favourable neurological outcome.
If the endpoints were independent, 65% power for each of nine endpoints would provide approximately 83% power to detect five of nine favourable trends.
In this situation StO2 provides a falsely favourable impression of adequate body perfusion, because of the inability to detect organ ischemia in the lower part of the body.
More often, blowflies (Diptera: Calliphoridae) are the first insects to detect the cadaver and, if the circumstances are favourable, to leave eggs on the body.
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