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Favourable targets for the directed evolution of new biocatalysts are the syntheses of highly complex molecules, especially where chemistry, metabolic engineering or recombineering provide a partial solution.
DELLA proteins have been proposed to be favourable targets for crop improvement on several occasions (Peng et al. 1999; Ikeda et al. 2001).
As specific substitutions such as Y > F and Q > N produce more favourable targets for distinct mucosal isolates, it is possible that occurrence of such receptor polymorphisms in the human population could lead to greater bacterial binding thus increasing the chances of cellular invasion.
Previous studies of Class I integron mobility within all of these genomes indicated that Actinobacteria, and Proteobacteria bacterial classes in particular, are highly favourable targets for horizontal gene traffic and may explain the abundance of SMR homologues within these particular classes [ 39, 40].
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Targeted radionuclide therapy combines "the favourable targeting properties of peptides and antibodies with the effectiveness of radiation-induced cell death.
For comparison purposes, the expected frequency of the target QTL given no selection (but identical amounts of backcrossing) was calculated as the expected genetic contribution of the donor population (based on pedigree) multiplied with the original frequency of the favourable target allele in the donor population.
In RA, the current results of array analyses [ 12] would not necessarily direct drug development towards the most favourable therapeutic targets such as TNF and IL-1.
Attachment of these compounds to a polymer backbone might result in more favourable cell targeting for Leishmania, although a report has indicated that polymer bound alendronate may still be targeted to the bone.
Our performance analysis aims at assessing which of the two channels is the more favourable for target detection.
The in vivo studies demonstrated specific tumour binding and favourable tumour targeting properties for both conjugates, albeit with higher tumour uptake, slower tumour dissociation, higher tumour-to-blood ratio and higher CD44v6 sensitivity for the 111In-labelled fragment.
The performance of both single-channel and multichannel detection schemes are evaluated by processing real sea clutter data collected by the NetRAD nodes, in order to evaluate which of the two channels, i.e. the bistatic and monostatic channels, is more favourable for target detection.
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