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Symptom-free patients were more common in early favourable stages and less common in advanced stages.
Our results support the latter study and show that LOH at 9p21 23 is more frequently found in favourable stages of NB.
In summary, we attribute most of the decline of mortality in Yorkshire in the 1990s to a generalised shift towards more favourable stages at diagnosis and earlier treatment.
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Women also had more favourable stage distribution (higher proportion of localised disease).
Australia and Sweden had quite favourable stage distributions at diagnosis and relatively high survival at all stages of disease.
A reduction in diagnostic interval could contribute towards lower mortality through a more favourable stage distribution and better treatment options.
Women showed more favourable stage distribution which may be related to the increasing use of modern abdominal imaging techniques.
Clinical excellence or favourable stage distribution that acted in the medium term should act in the short term as well.
These cancers would be expected to have favourable staging and mortality, but their symptoms may be vague or atypical, delaying the diagnosis.
There was a significant change to a more favourable stage distribution during the study period from the prescreening era to the screening era.
We found a more favourable stage distribution for patients with screen detected colorectal cancer compared with those in the control group and the non-attending group (table).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com