The favourable safety profile and clinical activity of GSK2857916 monotherapy support progress into larger later-phase trials.
Due to the favourable safety profile, these bioactive compounds are considered in the category "GRAS".
However, these drugs have a less favourable safety profile than newer antidepressants, such as the selective serotonin reuptake inhibitors (SSRIs).
Due to a potential favourable safety profile of axitinib (AX), a phase I study combining everolimus (EV) and AX for solid tumours was explored.
This agent has a generally favourable safety profile, and may be suitable for use in special populations such as the elderly and/or frail patient.
The safety and the efficacy of the vaccine has been reaffirmed by numerous independent investigations, including a 2015 report based on data from over a million individuals which concluded the vaccine had a favourable safety profile.
A favourable safety profile also makes EP an attractive option for in vivo immunisation.
Results from the current study also confirmed the favourable safety profile of nVNS that was reported in previous studies of nVNS in the treatment of migraine [25, 26].
In chronic migraine, botulinum toxin type A reduces frequency of migraine by three days/month, reduces migraine severity by 30% and has a favourable safety profile compared with other preventative drugs.
Importantly, CEN1 HC had a more favourable safety profile compared to the original peptide, with no lytic activity observed against mammalian cells at the concentrations tested, thus showing a clear dissociation of antibacterial and anti-eukaryotic cell activities.
Evidence of immunogenicity, efficacy and a favourable safety profile of the RTS,S/AS02 candidate malaria vaccine has been demonstrated in adults [13] [16] and subsequently in children and infants [7], [17] [21].
