Deleterious mutations occur much more frequently than mutations resulting in novel and favourable functions [ 17].
Whether the apoA-I Milano protein also provides an additionally favourable function on glucose metabolism has not been investigated, and the variant was therefore included in the present study.
Furthermore, the effects were also small and more favourable for specific functioning measures, as opposed to more global measures, small to moderate in terms of worse outcomes for follow-up periods >10 years, small to moderate for more unfavourable outcomes in males, and small to large for worse outcomes in studies including patients diagnosed before 1970.
The main finding of this study is that ToF-patients with an ICD show less favourable psychosocial functioning compared to ToF-patients without ICD and to the older acquired heart disease ICD-patients.
Type 4 fallers (persons who experienced a fall away from home during mobility-related activities) predominantly were younger (aged <80), more active and have the most favourable daily functioning (GARS) scores.
Also, avoiding hyperthermia by controlling body temperature is associated with a favourable neurologic function in survivors of cardiac arrest [ 6], as well as with earlier shock reversal in septic shock patients [ 7].
The recipients with a 2hPG ≥ 7.8 mmol/l were significantly older, had less favourable kidney function and were more likely to have a history of smoking, pre-transplant CVD, CMV infection and rejection than those with 2hPG < 7.8 mmol/l.
In the SOFA-matched group (Table 3), the patients with cirrhosis had a lower platelet count (P < .001), a higher Glasgow coma scale (GCS), a more stable haemodynamic status, more favourable renal function, a higher bilirubin level, and a lower albumin level compared with the patients without cirrhosis.
In conclusion, our results provide further evidence that DTC patients' burden from symptoms and functioning impairments is unrelated to the favourable clinical outcome.
Overall, the BBES showed favourable psychometric properties using multi-group confirmatory factor analyses and differential item functioning.
On physical functioning the ToF + ICD group obtained a higher, more favourable mean score than the ICD group (p = 0.01).
