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This then has to balance with the favourable effects of screening in order to be able to decide on an appropriate screening policy.
16 Firstly, as a result of increased detection of early stage tumours, possible favourable effects of screening on survival are generally overestimated since a large percentage of early stage screen detected tumours are indolent and have an excellent prognosis.
The amount of overdiagnosis, the increase in primary surgery/radiotherapy, and the longer time frame since diagnosis has to be weighed against the favourable effects of screening: about 750 breast cancer deaths prevented per year (16%), reduction of treatments for advanced disease and its consequences for quality of life, and 15 life-years gained if dying from breast cancer has been prevented.
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15 By comparing screen detected tumours with interval detected tumours, observed survival differences are often attributed to favourable effects of breast cancer screening, whereas the observed survival difference can be (partly) explained by differences in tumour biology.
Compared to the proven favourable effects of roundabouts on safety in general, this result is unexpectedly poor.
Both showed favourable effects of early administration.
Two RCTs assessed the occurrence of side effects of chemotherapy and showed favourable effects of moxibustion.
All of 4 RCTs failed to show favourable effects of moxibustion on response rate.
Theoretically, the favourable effects of cytoreduction may also be expected in patients with recurrent ovarian cancer.
In a previous pilot study, we demonstrated favourable effects of ASV on cardiac function [ 22].
Both studies showed favourable effects of moxibustion plus chemotherapy compared with chemotherapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com