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15 By comparing screen detected tumours with interval detected tumours, observed survival differences are often attributed to favourable effects of breast cancer screening, whereas the observed survival difference can be (partly) explained by differences in tumour biology.
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The long time lag (>20 years) between the last breast-feeding period and blood collection at the baseline examination might mask favourable effects of breast-feeding on metabolic variables in our analysis.
Administration of adjuvant chemotherapy (HR 0.70 95% CI 0.35 1.41) and of adjuvant hormonal therapy (HR 0.62, 95% CI 0.30 1.28) had a nonsignificant favourable effect on breast cancer-specific survival in the CHEK2 group.
The amount of overdiagnosis, the increase in primary surgery/radiotherapy, and the longer time frame since diagnosis has to be weighed against the favourable effects of screening: about 750 breast cancer deaths prevented per year (16%), reduction of treatments for advanced disease and its consequences for quality of life, and 15 life-years gained if dying from breast cancer has been prevented.
Both showed favourable effects of early administration.
Two RCTs assessed the occurrence of side effects of chemotherapy and showed favourable effects of moxibustion.
All of 4 RCTs failed to show favourable effects of moxibustion on response rate.
Theoretically, the favourable effects of cytoreduction may also be expected in patients with recurrent ovarian cancer.
In a previous pilot study, we demonstrated favourable effects of ASV on cardiac function [ 22].
Both studies showed favourable effects of moxibustion plus chemotherapy compared with chemotherapy.
All trials reported favourable effects of t'ai chi on pain reduction.
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