Their N-dealkylation orientations fit well into those CYP3A4 functional regions such as the B C loop, F G loop, I helix, and K−β loop in an energetically favored manner.
In this way, while bound to TBP, the middle six base pairs of the TATA box are in a partially unwound right-handed double helical conformation with a widened minor groove which fits in an energetically favored manner to the concave surface.
Meanwhile, the Zeitgeist favors all manner of do-gooding.
Instead, an image of the pontiff clasping the head of a microphone, in the manner favored by rappers, beatboxers and people who don't know how to properly hold a microphone, quickly went viral.
The Silver Parka The most seriously injured victim, Natania Reuben, said on the stand that Mr. Combs pulled a gun from the folds of his silver parka, which he wore in the slouchy, indifferent manner favored by rappers: halfway down his arms and drooped across his hips.
And Justice Anthony Kennedy, a Republican appointee seen as a swing vote, expressed concern that reading the law in the manner favored by the plaintiffs would create a "constitutional problem," since it would leave states a choice between establishing exchanges or seeing their insurance markets seriously damaged.
Using the same protein pull-down strategy with ROP2, an Arabidopsis RAC/ROP, as bait, we observed that LLG1 was also pulled-down by ROP2 and in a guanine nucleotide-dependent manner, favored by GDP, as was LRE.
But when the narrator evokes a common national good and purpose — unfurling our country's full name in the rhetorical manner also favored by our current president — you feel the graveyard's chill wind.
From the way the pictures were positioned on the wall and the way my grandparents had been posed (turned slightly toward each other, in the manner still favored by European kings and queens on stamps), anyone who met their haughty gaze would know at once that the story began with them.
Instead, treatment with AP5 resulted in significant reorganization of dendritic arbor in a manner that favored addition of dendritic segments of high branch orders, at the expense of those closer to the cell body.
These pathways were modulated by A20 in a manner that favored decreased inflammation, heightened proliferation, and optimized metabolic control and energy production.
