Acylhydrazone is a pharmacophore armed with favorable activity of antibiosis, anticancer and antivirus.
One of them, named J2, which possessed favorable activity, was obtained.
Compound 3a revealed favorable activity against tomato bacterial wilt in vitro compared with the commercial bactericide Kocide 3000.
In their research, several KN1022 (77) (Figure 2) derivatives with favorable activity were obtained, including 4- 4-methylphenoxy phenyl,4- 4-methylphenoxy phenylphenoxyphenyl.
Compared to natural superoxide dismutases, the artificial enzyme mimic exhibited favorable activity stability, indicating its promising applications in the in vivo long-term monitoring of superoxide anion.
The catalyst prepared by ethanol solution impregnation and dried at 120 °C (Ru/Al2O3-ED) gave a higher metal dispersion and more favorable activity and durability than that prepared in aqueous solution.
Furthermore, phase II monotherapy trials in patients with advanced non-small cell lung cancer, ovarian cancer, and head and neck squamous cell cancer, respectively, show favorable activity compared with single-agent chemotherapy in similar patient populations.
The results showed that the majority of the target compounds showed moderate to favorable activity against six kinds of susceptible strains and almost all of them displayed significantly improved activity compared with references against three erythromycin-resistant strains of S. pneumoniae B1 expressing the ermB gene, S. pneumoniae AB11 expressing the ermB and mefA genes, and S. pyogenes R1.
Further, in vitro/in vivo studies have also shown favorable activity against Candida albicans, Malassezia spp., and Aspergillus fumigatus.
