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The last but not least problem is with antibiotics, especially during the acute phase of sepsis, as the management of dosing is very difficult during RRT and is probably better to favor continuous methods than intermittent ones.
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Intense cross-border migration continues in both directions, favoring continuous virus transmission between Afghan and Pakistan [ 19].
A slow chemical reaction favors continuous nuclei, keeping always a certain number of nuclei in the system.
The density of states of the films at this nascent stage of SEI formation in contact with the Li metal surface are very different than those of the bulk crystals, usually showing new intermediate states between the metal and conduction bands, which suggests a change to an electronically conductive character that favors continuous reactivity.
Expert opinion, along with the aggregated results of two recent large randomized trials, favors continuous renal replacement therapy (CRRT) as preferential treatment for septic AKI (hemodynamically unstable).
Still a third school favors continuous veno-venous hemodiafiltration (CVVHDF) on the basis that without evidence, providing both modes is safest.
High IFN-γ directly modulates both cancer biology (e.g., by inducing tumor cell senescence) (Schwartzentruber et al., 2011; Bedognetti et al., 2013; Braumüller et al., 2013; Galon et al., 2013) and induces an immune contexture favoring continuous tumor cell elimination, a concept coined "cancer immune surveillance" (Shankaran et al., 2001).
This indeed could favor a continuous adaptation through remodeling processes to functional changes in the surrounding tissues [12, 13].
The need for optimal efficacy (reaching target values and minimizing variations) and for maximum safety (reducing the incidence of hypoglycemia) is nevertheless a strong argument in favor of continuous intravenous insulin infusion by an electric syringe pump.
Unfortunately, as only retrospective studies have provided evidence in favor of continuous infusion over intermittent infusion (especially in pathogens with higher MICs and in ventilator-associated pneumonia [ 7]), a prospective study in this setting is warranted.
In contrast, the dominance of the nitrogen-fixing Anabaena is not favored by continuous mixing but requires temporarily stratified conditions, as observed offshore (Gikuma-Njuru & Hecky, 2005).
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