Your English writing platform
Discover LudwigExact(4)
Ms. Ulrich said to use it more than 24 hours before a gathering, to give fabrics time to dry, but mine needed more time because a faulty attachment spewed a cascade of cleaning solution onto the chair instead of steam.
This kind of attachment activates the SAC in mitosis, therefore the question at issue was whether the SAC can recognize a faulty attachment in meiosis I in mammalian oocytes.
However, in meiosis I, sister kinetochores attach to microtubules with the same polarity (syntelic attachment), which is called mono-orientation [21], [24], [25], and homologous chromosomes segregate with monopolar kinetochore orientation, which in mitosis is regarded as a faulty attachment [23], [26].
In vertebrate cells, where kinetochore microtubule attachment can be visualized directly, it has been shown that Aurora-B is required to suppress merotelic attachment, possibly by destabilizing the faulty attachment (Cimini et al, 2006; Knowlton et al, 2006).
Similar(54)
We next investigated if the generated cells lines were able to correct faulty attachments when Mps1 was inhibited during error-correction rather than prior to the establishment of errors.
This dynamic instability is thought to aid the search and capture mechanism of kinetochore attachment, as well as the error correction process of faulty attachments.
To further assess whether MCAK re-localization in EGFP-Hec1 cells was connected to its function in the correction of faulty KT-MT attachments into functional end-on attachments, we induced siRNA-mediated depletion of MCAK in the cells that expressed EGFP-Hec1 (Figure 6C).
Correction of faulty kinetochore-microtubule attachments is essential for faithful chromosome segregation and dictated by the opposing activities of Aurora B kinase and PP1 and PP2A phosphatases.
The gradual increase of kMTs may help turn off the spindle assembly checkpoint in normal conditions but can promote a faulty conformation (merotelic attachments) to evade the checkpoint.
Attach lower attachment assembly.
In 2005, a study led by researchers at the University of California, Los Angeles, showed that a class of drugs called farnesyltransferase inhibitors (FTIs), which block the attachment of a molecule to the faulty protein that allows it to accumulate around the nucleus, restored normal shape to cells from kids with progeria.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com