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However, being a hydrogel, it exhibits low affinity for cell attachment, which is crucial for the cellular fate process.
An adjusted multimedia fate model has been developed which accounts for nano-specific fate process descriptors (i.e. sedimentation, aggregation with suspended particle matter, etc).
This hydrogel platform offers a facile means of in situ stiffening of cell-laden matrices and should be valuable for probing cell fate process dictated by dynamic matrix stiffness.
Mostly cells anchorage is dependent on the cell fate process such as proliferation, migration, and differentiation, whereas apoptosis is dependent on the cell adhesion pattern to the artificial/mimic scaffolds.
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Significant differences in fate processes were successfully detected.
Therefore, surface characterization methods are important to understand NP fate processes [56].
These data will certainly support the recent developments in NP fate modelling, namely simulations of individual fate processes and fate predictions in rivers and porous media [64, 120 123].
Environmental fate processes of ENMs which are mostly influenced by aggregation, transformation and sedimentation are non-equilibrium but kinetic processes.
Hypoxia is a critical condition governing many aspects of cellular fate processes.
In summary, predominantly qualitative information on particle fate in aquatic and porous media is available and key factors which control fate processes have been identified.
That accounts for the fact that environmental fate processes of ENMs are kinetic processes but not equilibrium processes as they are for conventional chemicals [5].
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