To produce the cell fate choice appropriate for a particular stage in the cell lineage, Notch signaling needs to interpret the cell context information for each stage and convert it into the appropriate cell fate instruction.
A longstanding question in mammalian development is whether the divisions that segregate pluripotent progenitor cells for the future embryo from cells that differentiate into extraembryonic structures are asymmetric in cell-fate instructions.
Divisions that generate ICM and TE progenitor cells were cautiously termed "differentiative" (Johnson and Ziomek, 1981) because it was unknown whether such divisions are asymmetric in transmitting cell-fate instructions or whether inside and outside cells follow different fates only because of the differential positions assumed by the cells.
Our results indicate that "differentiative" divisions in the mouse embryo contribute to the asymmetry of cell-fate instruction: they prevent inside cells from inheriting Cdx2 transcripts, thereby permitting the development of pluripotency while adding support to the differentiation program of outside cells.
Acutely aware of his fate, he has taped instructions to himself to guide him through every step of the great work of his life before darkness falls.
The witch gives Merida a spell-infused cake with only the instructions that it will "change her fate".
As I read, the air is tense with anxiety; the audience is silent, listening to the instructions as if they are a fate to be avoided.
Come November, voters will decide the fate of Proposition 58, which would repeal English-only instruction in public schools, allowing local parents and teachers to develop their own multilingual programs.
Her sister's nervousness is righteous as she (against hubby's instructions) surfs the Internet, researching predictions regarding the fate of Earth and planet Melancholia.
The important discovery here is that this 'sub-fate' is not a cell-autonomous translation of birth order instructions, but is rather subject to regulation by the choices of neighboring cells.
Here we present evidence for an alternative hypothesis: that there are a discrete number of cell populations that are of sufficient developmental plasticity to have their primary developmental instructions superseded and thereby allowing for the adoption of a retinal fate.
