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Dynamic modeling of cell fate exists, for apoptosis/necrosis [ 3] and for autophagy [ 4], in a single cell model.
Our mutant and temperature shift analysis of Notch signaling suggested that a window of competence for the IPC NB fate exists from the time the pPIm expanded to eight cells and acquired proneural competence until the time that IPC NB fate was normally specified (the time that it became Dac+).
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Yet, numerous examples of 'spontaneous change of fate' exist in the old literature, but they are often linked to post-natal tissue damage and regeneration.
To require a cross-level principle to be regular, or a lineage-tissue mapping to satisfy IIA, means that for any fixed context, that is, any given set of actually considered fates, the ranking of tissue fates should be independent of the very existence of alternatives outside the context, that is, independent of whether potential-but-actually-not-considered fates exist.
Since fluorescent fate markers exist for various systems, morphological quantification has been shown to be usable for fate recognition [ 47], and robust cell segmentation algorithms work on full time-lapse movies [ 16], we believe that adequate datasets from various cell systems will emerge in the near future.
Although speculation about the building's fate has existed for 15 years, the dancers' concerns are fed by the neighborhood's changing face.
By the end my stomach was clenched as I hoped fate really existed despite how cheesy fiction makes it out to be.
Thus, loss of the stabilizing effect of lateral signaling effectively moves the system towards a region in parameter space where the acinar cell fate no longer exists.
"I don't think their chances are as good if they don't take a proactive approach and try to blend the natural fates that exist out there with a proactivity," he said.
If such potential-but-not-actual fates do exist, the analysis should be independent of who they are and of what the lineages' propensity rankings over them are.
NuRD's role in maintaining the barrier between embryonic and trophectodermal cell fates in ES cells exists side by side with its function in facilitating embryonic lineage commitment (Fig. 6).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com