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Other genes must be involved in the respective fate determinations at their specific progenitor areas.
While RA may enhance skeletal myogenesis by expanding the progenitor population [ 53], bexarotene appears to affect germ layer fate determinations, and more specifically, promote mesoderm differentiation [ 46].
Therefore, our data not only highlight an intricate connection between fate determinations of both stem cell domains via the activity of Rx2.
The exact mechanism by which Lrp5 signaling controls MSC fate determinations, mechanical loading, osteoblast maturation, and proliferation is still under investigation.
This study thus offers a novel insight into carcinogenesis of human colon cancer and molecular mechanisms regulating fate determinations of human colon cancer stem cells.
Nodal belongs to the transforming growth factor beta (TGF- β) superfamily, and it plays essential roles in regulating embryonic development [ 10] and cell fate determinations [ 11, 12].
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This study identifies coreceptor gene imprinting as a critical determinant of lineage fate determination in the thymus.
Cytoplasmic determinants play a predominant role in cell fate determination [7].
Another attractive hypothesis is that cytoplasmic determinants may play a predominant role in cell fate determination [7].
When determining cell fate from biological points of view, several biological fate determination rules can be considered.
When determining cell fates from biological points of view, several biological fate determination rules can be taken into account.
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