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Dotted line indicates the percentage GFP spores expected if there is no fate bias.
Dotted line indicates the percentage RFP spores expected if there is no fate bias.
The molecular mechanisms and gene regulatory networks controlling cell fate bias and lineage priming remain largely unknown.
Like cell fate bias, cell competition is thus based on measurements of relative fitness between neighboring cells.
3) It was not clear why you think that variations in transcription of RasD could relate to cell fate, given that it is the levels of activated Ras that seem to relate to cell fate bias.
That loss of p27kip1 did not impact the cell fate bias of H2B-nonLRCs argues for its importance for maintaining the self-renewal potential of primitive stem cells and redundancy in their more committed progeny.
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However, the cellular signaling pathways regulating vibration-induced cell differentiation remain unclear and further investigation may elucidate underlying molecular mechanisms that determine cell fate by biasing the lineage commitment of BM-MSCs.
In recent years, several models have been applied to elucidate the evolutionary fates and biased retention of duplicated genes, such as subfunctionalization, neofunctionalization, and dosage balance [ 60].
The trophectoderm is specified between the morula and blastocyst stages of embryonic development, although some of the cues that initiate specification may occur at the late 8-cell stage and other factors that bias fate choice may occur even earlier [48].
Their genetic role in specifying sperm fate, their genomic bias for oogenic mRNAs, their physical interaction in nematodes plus knowledge from other organisms that their homologs can repress mRNAs, taken together, support the model that FOG-1 and FOG-3 work in a complex to repress the oogenic program.
These retinoblastomas might arise in a RPC in which the stochastic regulation of cell fate is strongly biased towards a cone cell lineage.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com