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Mutually antagonistic interactions between BOP and meristem factors are important in maintaining a border between meristem-organ compartments and in controlling irreversible transitions in cell fate associated with differentiation.
These data suggest that ADAR1 deletion leads to an expansion of progenitors and skewed Paneth cell fate, associated with abnormal Wnt signaling.
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While none of the ExEn cell lines that we assessed expressed markers for the definitive endoderm, it remains to be determined if these cells can be coaxed by the addition of growth factors to differentiate along definitive endoderm lineages and adopt fates associated with the gut or its associated organs.
Increased or decreased YAP activity reprograms subsets of hepatocytes to different fates associated with deregulation of the HNF4A, CTNNB1, and E2F transcriptional programs that control hepatocyte quiescence and differentiation.
These findings demonstrate that elements of pathologic tumor plasticity mirror the normal developmental history of organs in that cancer cells acquire cell fates associated with developmentally related neighboring organs.
Therefore, monocytes have two potential fates associated with distinct patterns of migration.
In the telomerase mutant mouse model, lack of p53 allows dysfunctional cells to avoid fates associated with checkpoint activation, including growth arrest and apoptosis [24], [25].
Perturbations of these Notch pathway components can lead to aberrant cell fates associated with human disorders and diseases.
We next assessed the fates associated with the in vivo stained KLRG-1int and KLRG-1hi effector cells.
However, β-catenin exploits both TCF activation-dependent and -independent signaling to regulate proliferation at different developmental stages as well as distinct cell fates associated with consecutive waves of sensory neurogenesis.
Laima, also called Laima-dalia, (from Lithuanian laimė, "happiness," "luck"), in Baltic religion, the goddess of fate, generally associated with the linden tree.
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