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Considering the recent emergence of a rapidly progressing viral infection leading to encephalitis with high fatality proportion in children from India and the absence of any specific treatment, RNAi based interventions were explored to suppress CHPV infection in mice.
The case fatality proportion (CFP) was calculated as the number of deaths among the cases of influenza A that occurred during hospitalization or within six weeks of discharge divided by the total number of cases of influenza A among hospitalized pneumonia patients.
The case fatality proportion of hospitalised CAP patients was 9.8%.
In several other outbreaks, the case fatality proportion (CFP) has been substantial.
Among 174 CAP cases, 17 patients died (case fatality proportion = 9.8%); eight were aged < 65 years (CFP = 7.3%), and nine were aged ≥ 65 years (CFP = 15.8%).
The one-month case fatality proportion remained stable at 35% over the study period, and was associated with advanced age, like in our previous study from years 1995-1999 [ 29].
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We calculated the normalised peak (peak AR/median AR) for datasets with a median AR greater than zero, to adjust approximately for differences in case definitions (this approach has been used elsewhere to adjust for intercity differences in case fatality proportions 5).
Finally, we discuss the implications for estimating the case-fatality proportion of this infection in Mexico.
In a growing epidemic, given a significant delay from illness onset to death [5], one expects to underestimate the case-fatality proportion as the deaths reflect cases from an earlier, smaller phase of the epidemic [6].
While it might be tempting to calculate a case-fatality proportion by dividing this number by the estimated number of cases in Mexico, such a calculation would likely be misleading, for several reasons.
Nonetheless, as the number of deaths accumulates, especially if illness onset dates are available for fatal cases, our estimates may provide an appropriate denominator for revised estimates of the case-fatality proportion.
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