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A potentially fatal side effect of metformin is the accumulation of lactic acid in blood and tissues, often causing vague symptoms such as nausea and weakness.
But clozapine has been less popular than its competitors because patients who take the medication must have frequent blood tests for agranulocytosis, a blood disorder that is an infrequent but potentially fatal side effect.
He says he also thinks it could be a lifesaver for those rare individuals who develop acute kidney injury, or AKI, a potentially fatal side effect of cardio-bypass surgery that results in often irreversible organ damage.
Bristol-Myers had previously applied to the Food and Drug Administration for approval of Vanlev as a blood pressure treatment, but withdrew that application when patients using the drug developed angioedema, a potentially fatal side effect, more frequently than patients treated with older blood pressure drugs.
And Johnson and Johnson and Bayer Corp. are being sued based on allegations that they deliberately concealed the blood thinner Xarelto's potential fatal side effect of internal bleeding.
Lactic acidosis is a potentially fatal side effect of nucleoside analog reverse transcriptase inhibitors (NRTIs) [1], [2], which are commonly used in combination antiretroviral therapy (ART).
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Chemotherapy is prescribed with no guarantee of effectiveness and can cause wretched, and sometimes fatal, side effects.
Chloramphenicol (Cam), although an effective antibiotic, has lost favour due to some fatal side effects.
Understanding patient-specific differences in risk tolerance for new treatments that offer improved efficacy can assist in making difficult regulatory and clinical decisions for new treatments that offer both the potential for greater effectiveness in relieving disease symptoms, but also risks of disabling or fatal side effects.
Some clinical trials have been halted abruptly as patients developed severe or fatal side effects.
Potentially fatal side effects, although rare, are also not fully understood.
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