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Furthermore, there is clear evidence that skeletal muscle oxidative capacity [46]−[48], capacity for fat utilisation [47], [49] and insulin sensitivity [50]−[52], are governed not only by mitochondrial function, but also capillary density and recruitment.
Although equine diets are typically high in carbohydrates and low in lipids, it has been found that chronic adaptation to fat-fortified feeds confers benefits to athletic performances of horses that may be due to enhanced insulin sensitivity and fat utilisation [103].
Higher intensity PA typically promotes liver glycogen catabolism 38 39 which may promote fat utilisation via this liver brain adipose neurocircuitry.
The relationship between the Rfat and Pfat was described by the least squared regression: (27) R fat = 0.489 + 0.547 × (P fat ), which explained 98% of the variance in the fat utilisation ratio (Rfat).
This results in a pronounced change in whole body fuel selection with an initial nutrition phase of high carbohydrate utilisation and a prolonged starvation phase of primarily fat utilisation that lasts until the next feeding 21.
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The predominance of fat over protein utilisation in the first few weeks of starvation is consistent with empirical measurements of substrate oxidation during starvation (Owen et al., 1998) and body composition measurements (reviewed by Heymsfield et al., 2011).
This supports the suggestion that low oxidative capacity/capacity for fatty acid utilisation is a central feature of the South Asian insulin resistance phenotype, and highlights the fact that the lower cardiorespiratory fitness and reduced capacity to oxidize fat in this group are likely to largely reflect the same underlying mechanism.
We can define the relative utilisation of fat and protein by a ratio (Rfat; the proportion of total energy utilisation that comes from fat): (22) R fat = E fat / (E fat + E prot ).
That is, the utilisation of fat and protein is not a simple linear reflection of their availability in the body.
Overexpression of PGC-1 α in human adipocytes enhances mitochondrial activities prompting white adipocytes away from fat storage towards lipid utilisation (Tiraby et al, 2003).
To explore the relationship between the proportion of the body that comprises fat (PFAT), and the utilisation of fat during weight loss (Rfat) we calculated the fat (FW1) and lean (LW1) contents of the body corresponding to a given body weight (BW1) using the data for the same cohort of 592 individuals (Speakman and Westerterp, 2010).
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