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The main components of this pathological state are anorexia and metabolic abnormalities, such as glucose intolerance, fat depletion and muscle protein catabolism among others.
This is a particularly intriguing finding since it has been shown that the insulin resistance of morbid obesity can be reversed by intramyocellular fat depletion [49].
Lipoatrophy is characterized by subcutaneous fat depletion in the face, arms, legs, and buttocks.
Several factors derived from tumours and/or host tissues are implicated in fat depletion during progressive cachexia (Tisdale, 2005).
They showed that DNA damage triggered a chronic autoinflammatory reaction, which in turn caused fat depletion in their mouse model (29).
From the earliest days of the investigation, fungal-influenced, hyper-frequent arousals from hibernation were hypothesized to cause premature fat depletion and death in WNS bats.
Similar(46)
Generally, fatty acids with shorter and more unsaturated carbon chains are more readily mobilized during fat store depletion [34].
UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction.
In Study 1, 72 participants completed baseline and follow-up measures of inhibitory control, self-regulatory depletion, fat intake and body-mass index.
Weight loss due to fat and muscle depletion is a hallmark of pancreatic cancer and is associated with worse outcomes.
Adiponectin levels were higher in patients with fat-free mass depletion.
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