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The list of genes associated with 'body fat abnormalities' and brain expression in the mouse may be interesting candidates to consider in future obesity studies.
For example, we see a correlation between 'total body fat' abnormalities and genes expressed in the 'brain', which fits recent discoveries linking genes expressed in the hypothalamus to obesity.
The heterogeneity of body fat abnormalities among HIV-infected patients, as well as the incompletely understood pathophysiologic mechanisms and the role of antiretroviral therapy, make management decisions difficult to devise.
As to the evolution of body fat abnormalities, evidence has been gathered that once body changes become clinically evident, they generally tend to persist, improving only in a minority of cases [ 9].
As a growing body of clinical evidence suggests that newer HAART regimens may be less toxic on the adipose tissue, causing a clear-cut lower rate of body shape changes in the long run [ 17], prevention of lipodystrophy should become a key issue when tailoring individual regimens, particularly for patients at high risk of developing fat abnormalities on the basis of the available data.
The final example of an association between genes expressed in the 'brain' and 'total body fat' abnormalities is intriguing because, as described in the Introduction section, many recent studies have highlighted the role that genes expressed in the 'brain' play a role in obesity.
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The extent of brown fat abnormality observed in OGR1 KO mice did not clearly affected the mouse physiological function in these mice under normal living conditions.
The combination of thickened PF and fat pad abnormalities on lateral plain radiography has a sensitivity of 85% and specificity of 95% for plantar fasciitis [19].
As stated above, calcaneal spurs are not specific for plantar fasciitis and are often identified in asymptomatic individuals; however, a strong association between spurs and chronic plantar heel pain has been demonstrated, specifically in cases of concurrent fat pad abnormalities [77].
HIV-related fat distribution abnormalities, commonly associated with lipid disturbances, have been described in the past as more frequent in women [ 15].
In multivariate logistic regression modeling, fat distribution abnormalities due to ART were an independent risk factor for subsequent non-adherence in adults [ 5].
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